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Lecturer(s)
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Pelikán Jakub, Mgr. Ph.D.
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Nuruyev Jiří, doc. Mgr. CSc.
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Course content
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1st lecture Introduction to the study of organic chemistry, history and development of organic chemistry. Types of organic compounds. Covalent bond, theory of molecular orbitals, single, double and triple bound. Writing chemical formulas. Models of organic molecules and their imaging. Isomerism, geometric isomerism (cis-trans, E / Z, syn-anti), optical isomerism, optical activity. Factors affecting covalent bonds (inductive effect, conjugation, Mesomeric effect). 2nd lecture Course of organic compound reactions (factors affecting the organic compound reactions, types of organic reactions, examples of reaction mechanisms). 3rd + 4 lecture Characterization and identification of organic compounds. (Isolation of the chemical individual, verification of purity, elementary analysis, determination of relative molecular weight. Principles of the physico-chemical methods of structure study, colourfulness of the compounds). 5th lecture + 6 lecture Hydrocarbons (alkanes, cykloalkanes, alkenes, alkynes, hydrocarbons with multiply bonds). Cyclic hydrocarbons with more cycles and cyclic hydrocarbons with multiply bonds. 7th lecture Alkyl halides, nitrocompounds, amines. 8th lecture Aromatic hydrocarbons (benzene structure, description of aromatic state, stabilization energy, the most important aromatic hydrocarbons). Electrophilic substitution (reagents, conditions and rules of electrophilic substitution). 9th lecture Substituted derivatives of aromatic hydrocarbons (halogenated derivatives, sulfonic acids, nitrocompounds, amines, phenols, carbonyl compounds, carboxylic acids, multifunctional aromatic compounds). 10th lecture Oxygenous derivatives (alcohols, ethers, esters of inorganic acids, carbonyl compounds, dicarbonyl compounds, ketenes, carboxylic acids, dicarboxylic acids, unsaturated mono-and dicarboxylic acids). 11th lecture Functional derivatives of carboxylic acids (Acyl halides, anhydrides, amides and imides, nitriles, esters, orthoestery). Substitution derivatives of carboxylic acids (halogenoacids, nitroacids, amino-acids, hydroxyacids, aldo- and keto-acids). Derivatives of carbonic acid. Derivatives of cyanic acid and isocyanic acid. 12th + 13. lecture Heterocyclic compounds (general characteristics, principles of nomenclature, the most important reactions of heterocyclic compounds, examples of syntheses). Note: The nomenclature of organic compounds is discussed as part of thematic units of the individual lectures. Seminars are conducted in response to issues lectured. Subject matter that is not lectured - natural compounds and antibiotics - students will prepare for the exam by self study from recommended literature and using tuitions. Study of the natural compounds includes: Saccharides (monosaccharides, oligosacharides, poly saccharides - the fundametals of saccharide chemistry, cyclic structure of saccharides). Lipids - general characteristics, classification, meaning. Amino acids (a-amino acids of proteins, their reactions and characteristics, peptide bond, peptides, polypeptides, proteins. Nucleic acids (structure and meaning). Terpenes (types of terpenes, the most important examples). Steroids (definition of notion, basic structures, examples of biologically important steroids). Alkaloids (definition of notion, examples of alkaloids). Natural dyes (colourfulness conditions, examples of dyes).
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Learning activities and teaching methods
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Lecture supplemented with a discussion, Lecture, Seminar
- Contact hours
- 65 hours per semester
- Preparation for comprehensive test (10-40)
- 40 hours per semester
- Preparation for an examination (30-60)
- 60 hours per semester
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| prerequisite |
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| Knowledge |
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| to orient the basics of secondary chemistry (structure) |
| described the principles of general chemistry |
| orientate in the system of inorganic chemistry (relations to the periodic system of elements) |
| to master the fundamentals of high school organic chemistry |
| Skills |
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| work with professional literature |
| record the course of chemical reactions |
| to master the terminology principles at secondary school chemistry |
| orientated in available information sources |
| learning outcomes |
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| Knowledge |
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| to distinguish the mechanisms of organic-chemical reactions |
| to divide organic compounds into individual homologous series |
| to control the principles of the nomenclature system of organic chemistry |
| Skills |
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| to propose the preparation of the compound on the basis of knowledge of its structure |
| compile the organic compound model and predict its properties |
| assign the name of the organic compound to the given formula, and vice versa |
| to work with information sources |
| teaching methods |
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| Knowledge |
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| Lecture |
| Lecture supplemented with a discussion |
| Seminar |
| assessment methods |
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| Combined exam |
| Test |
| Skills demonstration during practicum |
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Recommended literature
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Červinka O., Dědek V., Ferles M. Organická chemie. SNTL/Alfa Praha, 1980.
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Hrnčiar P. Organická chémia. SPN Bratislava, 1982.
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MCMURRY J. Organická chemie. VŠCHT Praha, 2015. ISBN 978-80-7080-930-3.
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Pacák, Josef. Stručné základy organické chemie. Praha : SNTL, 1978.
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Paleta, O.; Panchartek, J.; Trška, P.; Večeřa, M. Řešené úlohy z organické chemie. Praha: SNTL, 1981.
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SMITH, M. B., MARCH, J. March's Advanced Organic Chemistry. A Wiley-inetrscience Publication, John Wiley & Sons, Inc., New York, 2001. ISBN 0-471-58589-0.
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SVOBODA J. Organická syntéza I. VŠCHT, Praha, 2000. ISBN 80-7080-385-1.
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SVOBODA J. Sbírka příkladů z organické syntézy I. VŠCHT, Praha, 2000. ISBN 80-7080-386-X.
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