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Lecturer(s)
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Mrázová Tereza, RNDr. Ph.D.
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Jiřincová Vlasta, RNDr. Ph.D.
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Course content
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Lectures 1. Basic mechanisms of endocrine regulation - Integration systems of the organism - Endocrine glands and an overview of individual hormones and their functions 2. Hormonal regulation of metabolic processes - Intermediate metabolism - Homeostasis 3. Thyroid gland I - Anatomical data - Formation and secretion of thyroid hormones - Transport and metabolism of thyroid hormones 4. Thyroid gland II - Effects of thyroid hormones - Clinical manifestations - Laboratory tests of the thyroid gland: interpretation and indications 5. Endocrine function of the pancreas - The structure of the cells of the islets of Langerhans - Insulin biosynthesis and secretion - Laboratory analyses 6. Regulation of carbohydrate metabolism - Effects of insulin and its mechanism - Glucagon - Hypoglycemia and diabetes mellitus 7. Adrenal medulla - Morphology of the adrenal glands - Adrenal medulla: structure and function of medullary hormones 8. Adrenal cortex - Adrenal cortex: structure of adrenocortical hormones - Effects of glucocorticoids, cortisol secretion - Effects of mineralocorticoids, aldosterone secretion - Laboratory examination for disorders of adrenal hormone metabolism 9. Hormonal control of calcium metabolism - Metabolism of calcium and phosphorus - Vitamin D - Parathyroid glands - Calcitonin - Laboratory examination of bone metabolism 10. Pituitary gland - Morphology and distribution of hormones secreted by the pituitary system - Middle lobe hormones - Growth hormone and growth physiology - Hormones of the posterior lobe of the pituitary gland: oxytocin, vasopressin 11. Gonads - Male reproductive system: secretion of sex hormones - Female reproductive system: secretion of sex hormones - Menstrual cycle-hormonal regulation 12. Endocrine function of kidneys and heart - Renin-angiotensin system - Erythropoietin - Heart hormones 13. Endocrine function of adipose tissue, GIT and pineal gland - Adipose tissue hormones - Hormones of the gastrointestinal tract - Pineal gland 14. Diseases of the endocrine system - Etiology of endocrinopathologies - Clinical picture - Diagnostics - Therapy 15. Credit test
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Learning activities and teaching methods
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- Contact hours
- 30 hours per semester
- Preparation for comprehensive test (10-40)
- 20 hours per semester
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| prerequisite |
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| Knowledge |
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| to list the endocrine glands and describe them anatomically |
| Skills |
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| to assign individual hormones to specific endocrine glands that produce them |
| Competences |
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| N/A |
| N/A |
| learning outcomes |
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| Knowledge |
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| defines the endocrine system as one that adjusts and synergizes the activities of a number of body systems to match the changing conditions of the external and internal environment |
| will explain the importance of the endocrine system in the context of other metabolic pathways in the human organism |
| characterizes basic hormones in terms of their chemistry and physiological function |
| will describe basic laboratory endocrine screening |
| Skills |
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| based on laboratory data, performs a simple diagnosis of diseases of the endocrine system |
| Competences |
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| N/A |
| teaching methods |
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| Knowledge |
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| Lecture |
| Skills |
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| Task-based study method |
| Competences |
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| Task-based study method |
| assessment methods |
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| Knowledge |
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| Test |
| Skills |
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| Test |
| Competences |
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| Test |
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Recommended literature
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Beránek, M., Tichý, M. a kol. Vybrané kapitoly z klinické biochemie pro studijní program Zdravotnická bioanalytika.. Praha: Karolinum, 2013. ISBN 978-80-246-2186-9.
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Brunová J., Bruna J. Clinical endokrinology and diagnostic imaging.. Praha: Karolinum, 2014. ISBN 978-80-246-2058-9.
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Ganong WF. Přehled lékařské fyziologie.. Praha: Grada, 2005. ISBN 80-7262-311-7.
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Jabor A., Franeková J., Kubíček Z. Principy interpretace laboratorních testů.. Praha: Grada, 2020. ISBN 978-80-271-1272-2.
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Kršek, M. Endokrinologie.. Praha : Galén, 2011. ISBN 978-807262-783-7.
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Navrátil L. a kol. Vnitřní lékařství pro nelékařské zdravotnické obory, 2., zcela přepracované a doplněné vydání. Praha: Grada, 2017. ISBN 978-80-271-0210-5.
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ŠEBLOVÁ, J., KNOR, J. a kol. Urgentní medicína v klinické praxi lékaře.. Praha : Grada, 2018. ISBN 978-80-271-0596-0.
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Štěpánková, Š. Obecná biochemie.. Pardubice: Fakulta chemicko-technologická, 2020. ISBN 978-80-7560-342-5.
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Trojan S. a kol. Lékařská fyziologie.. Praha: Grada, 2013. ISBN 80-247-0512-5.
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Zadák, Z., Havel, E. Intenzivní medicína na principech vnitřního lékařství. 2. vyd.. Praha: Grada, 2017. ISBN 978-80-271-0282-2.
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Žofková I. Osteologie a kalcium-fosfátový metabolismus.. Praha: Grada, 2012. ISBN 978-80-247-3919-9.
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