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Lecturer(s)
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Course content
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1. Introduction to genetics. Molecular level of genetic processes. 2. Organization of the eukaryotic and prokaryotic genome. Replication, transcription, translation and regulation. Mutations, types, distribution and causes of their occurrence. 3. General Genetics - Mendel, basic concepts and laws. 4. General patterns of inheritance of multicellular organisms. Vertical transmission of genetic information. Gene Interactions. Letal genes. 5. Genomic binding, chromosome mapping and three-point test. 6. Inheritance and gender. 7. Inheritance of quantitative characters. Basics of statistics. Multiple alleles. 8. Inherited blood systems. HLA system. Non-small inheritance. 9. Genetics of populations. Relationships between genotype and allele frequencies. Using the Hardy-Wainberg principle. 10. Molecular evolution. Neutral theory of molecular evolution. 11. Human genetics. Genealogy and forecasting calculations. Fundamentals of Clinical and Biochemical Genetics. 12. Gene Engineering, Biotechnology and gene therapy. DNA diagnostics. 13. Eugenics and perspectives of medical genetics. Genetic prognosis and prevention. Prenatal diagnostics.
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Learning activities and teaching methods
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Cooperative instruction, Skills demonstration, Task-based study method, Individual study, Lecture, Lecture with visual aids, Practicum
- Contact hours
- 13 hours per semester
- Practical training (number of hours)
- 13 hours per semester
- Preparation for comprehensive test (10-40)
- 22 hours per semester
- Preparation for laboratory testing; outcome analysis (1-8)
- 4 hours per semester
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| prerequisite |
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| Knowledge |
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| To know the basics of molecular biology from the last semester To master secondary school mathematics To know the professional terms of general biology at the gymnasium level Know the molecular level of genetic processes Know the organization of the eukaryotic and prokaryotic genome |
| Skills |
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| Know the basics of molecular biology from the last semester To master secondary school mathematics |
| Competences |
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| N/A |
| N/A |
| learning outcomes |
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| Knowledge |
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| Know the molecular level of genetic processes. |
| Know the organization of the eukaryotic and prokaryotic genome |
| Know gene interactions, lethal genes, gene bonding. |
| Knowing chromosome mapping and three-point test, inheritance and gender, inheritance of quantitative characters. |
| Know basics of statistics, multiple alleles, heredity of blood systems, HLA system, extra-nuclear heredity |
| To know the basics of clinical and biochemical genetics. |
| Skills |
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| Use correctly genetics terminology. |
| To be able to orientate in the foundations of genealogical trees. |
| To be able to easily compute and solve problems in genetics. |
| To be able to take care of some living genetic models. |
| Competences |
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| N/A |
| N/A |
| teaching methods |
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| Knowledge |
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| Lecture |
| Lecture with visual aids |
| Practicum |
| Task-based study method |
| Skills demonstration |
| Cooperative instruction |
| Individual study |
| Lecture supplemented with a discussion |
| assessment methods |
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| Written exam |
| Skills demonstration during practicum |
| Continuous assessment |
| Skills |
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| Test |
| Competences |
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| Test |
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Recommended literature
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Alberts, B. a kol. Základy buněčné biologie. Ústí nad Labem, 1998.
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Pritchard, D., J. a Korf, B., R. Základy lékařské genetiky. Semily, 2007.
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Rosypal, S. Úvod do molekulární biologie. Brno, 2006.
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SNUSTAD D.P., SIMMONS M.J. Genetika. Masarykova univerzita v Brně, 2017. ISBN 978-80-210-8613-.
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