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Lecturer(s)
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Krausová Andrea, RNDr. Ph.D.
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Course content
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1. History of cell biology. Cell theory (J.E. Purkyně). 2. Prokaryotic and eukaryotic cells. Subcellular organisms. 3. Cell organelles of eukaryotic cells (structure and function). 4. Membrane system of the cell. Transport of molecules across membranes. 5. Skeletal principle of the cell (microtubules, microfilaments, intermediate filaments, nuclear skeleton). Mechanisms of movement at the cellular and subcellular level. 6. Energy relations in the cell. Mitochondria. Respiratory chain (oxidative phosphorylation). 7. Cell nucleus and chromatin (structure and function). 8. Cell reproduction. Cell cycle and its regulation. Mitosis. Meiosis. 9. Extracellular matrix. Cell signalling. 10. Cellular response to stress. Cell death (necrosis and apoptosis). 11. History of molecular genetics. Chromosome theory of heredity (T. Morgan, T. O. Avery). The discovery of the structure of DNA, the central dogma of molecular genetics (J. Watson, F. Crick, R. Franklin). 12. DNA structure and the genetic code. Genetic information: gene definition, gene structure. Structure and types of RNA. Proteins. 13. Mechanism of DNA replication. 14. Expression of genetic information, transcription, translation, transcription factors. 15. Regulation of gene expression. mRNA. Epigenetics.
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Learning activities and teaching methods
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Lecture
- Contact hours
- 45 hours per semester
- Preparation for comprehensive test (10-40)
- 10 hours per semester
- Preparation for an examination (30-60)
- 30 hours per semester
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| prerequisite |
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| Knowledge |
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| specific knowledge prerequisites are not required |
| Skills |
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| specific skill prerequisites are not required |
| Competences |
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| N/A |
| learning outcomes |
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| Knowledge |
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| describes cell organelles at the cellular and subcellular level, explain their importance in connection with the function of the cell |
| defines the molecular principles of cell division |
| explains the principles of cellular functions such as movement, reception of substances and signals, response to stress, cell death, etc. |
| Skills |
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| masters the basic terminology of cellular and molecular biology |
| Competences |
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| N/A |
| teaching methods |
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| Knowledge |
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| Lecture |
| Skills |
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| Lecture supplemented with a discussion |
| Competences |
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| Lecture |
| Lecture supplemented with a discussion |
| assessment methods |
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| Knowledge |
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| Test |
| Oral exam |
| Skills |
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| Oral exam |
| Competences |
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| Oral exam |
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Recommended literature
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ALBERTS, Bruce a kol. Základy buněčné biologie: Úvod do molekulární biologie buňky. 2. vydání. Ústí nad Labem: Espero, 2006. ISBN 80-902906-2-0.
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Gerald KARP, Janet IWASA & Wallace MARSHALL. Karp's Cell and Molecular Biology. 9th Edition. Hoboken: Wiley, 2020. ISBN 978-1-119-68820-4.
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OTOVÁ, Berta, Romana MIHALOVÁ A Klára BOBKOVÁ. Základy biologie a genetiky člověka. Vydání druhé.. Praha: Karolinum, 2020. ISBN 978-80-246-4565-0.
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SLABÝ, Ondřej. Lékařská biologie I: buněčná a molekulární biologie. 1. vydání.. Brno: Masarykova univerzita, 2022. ISBN 978-80-280-0060-8.
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SNUSTAD, D. Peter a Michael J. SIMMONS. Genetika. Druhé, aktualizované vydání. RELICHOVÁ, Jiřina (ed.). Brno: Masarykova univerzita, 2017. ISBN 978-80-210-8613-5.
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VYSKOT, Boris. EpiGenetika. Olomouc: Univerzita Palackého. 2010.
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