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Lecturer(s)
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Navrátilová Dana, MUDr.
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Vorlíčková Soňa, MUDr.
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Course content
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History of genetics and its division. Cell cycle and mitosis. Meiosis. Gameto-genesis in man and woman. Structure and function of DNA. Gene and transfer of genetic information. Mendel?s laws. Basic notions: genotype, fenotype, dominance, recessive, homozygote, heterozygote, types of heredity. Analysis of genealogical trees. Karyotype, structure of chromosome. Investigation methods in cytogenetics. Origin and types of chromosomal abberations, numeric chromosomal abberation, structural chromosomal aberration. Syndroms: Down, Edwards, Patau, cat cry, Klinefelter, XYY, Turner. Possibilities of prenatal diagnostics. Investigation methods in molecular genetics. Genetic engineering and possibility of treating hereditary disorders. Genetic counselling. Prenatal diagnostics and genetics. Hereditary disorders of metabolism, possibilities of treatment and filing. Influence og mutagenic factors in the environment and testing possibilities. Ecogenetics. Pharmacogenetics. Immunogenetics. Process of carcino-genesis: types of mutations in particular types of malignancies. Population genetics. Genetics and society.
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Learning activities and teaching methods
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Lecture supplemented with a discussion, Multimedia supported teaching
- Contact hours
- 22 hours per semester
- Preparation for an examination (30-60)
- 30 hours per semester
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| prerequisite |
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| Knowledge |
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| No particular prerequisites specified. |
| learning outcomes |
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| Students will learn basic laws of genetics. They will recognize genetically conditioned diseases and disorders. They will be able to choose appropriate cytogenetic and molecular-genetic investigation methods. |
| teaching methods |
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| Lecture supplemented with a discussion |
| Multimedia supported teaching |
| assessment methods |
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| Oral exam |
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Recommended literature
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Michalová, K. Úvod do lidské cytogenetiky. Brno, 1999.
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Pritchard, D. - Korf, B. Základy lékařské genetiky. Praha: Galén,, 2007.
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Snustad, D. - Simmons, M. Genetika. Brno: Nakladatelství Masarykovy univerzity, 2009.
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Thomson and Thomson. Klinická genetika, 6. vydání. 2004. ISBN 80-7254-475-6.
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