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Lecturer(s)
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Neckář Pavel, doc. Ing. Ph.D.
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Parvulescu Tomáš, doc. Ing. Ph.D.
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Course content
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The Biomaterials course provides students with a comprehensive view into the preparation, properties and application of a wide range of materials suitable for medical applications. The course aims to introduce students to topics in tissue engineering. The student will learn about the chemical and physical properties of bioactive materials in the body environment, techniques for preparing materials and the possibilities of their characterization. The course introduces new developments based on current knowledge in the presented subject matter. 1. Volumetric and surface properties of materials. 2. Cells and proteins. Immunology, inflammation and toxicity. 3. Natural biomaterials, biofunctional materials. 4. Metals as biomaterials. Stainless steels, alloys Fe/Co/Ti; mechanical properties. 5. Polymers as biomaterials. Biodegradable materials. 6. Hydrogels, bioresorbable and bioerosive materials. 7. Solid materials - ceramics, glass, glass ceramics, carbon. 8. Composites. Thin layers,coatings, graftings. 9. Biological response to implants. Biocompatibility. Haemocompatibility. 10. Soft tissue replacement I (sutures, skin.), 11. Soft tissue replacement II (cardiovascular, pulmonary) 12. Hard tissue replacement - reparation of long bones. 13. Chemical, biological, and mechanical degradation in biological environment.
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Learning activities and teaching methods
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Skills demonstration, Self-study of literature, Lecture, Practicum
- Presentation preparation (report) (1-10)
- 5 hours per semester
- Contact hours
- 39 hours per semester
- Preparation for an examination (30-60)
- 35 hours per semester
- Graduate study programme term essay (40-50)
- 40 hours per semester
- Preparation for comprehensive test (10-40)
- 10 hours per semester
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| prerequisite |
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| Knowledge |
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| Passing exams in chemistry, physics, materials science Ability to explain the structure and basic properties of metallic Ability ro explain bonds in nonmetallic materials (polymers and ceramics); their properties To explain structure of basic natural polymers and To describe possible degradation of all types of materials To become oriented in hydrophobic/hydrophilic properties of materials and surfaces |
| Skills |
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| To describe and solve reactivity and stability of metals in various environments To describe and solve reactivity and stability of nonmetals in various environments To describe and solve structure of natural polymers and their stability To describe and solve various types of degradation of different materials To solve mechanical and chemical stability of all material types in various environments |
| Competences |
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| N/A |
| N/A |
| learning outcomes |
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| Knowledge |
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| To explain possibilities of tissues/organs replacement in the human body Ability to list materials used as bioreplacements; their comparison, strength and weakness To predict degradation of different materials in the living body To describe the response of organism on existence of foreign material in the body Multicriterion selection of the optimal material |
| Skills |
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| To evaluate properties that an ideal material incorporated into the body should have To analyze basic and specific properties/behaviour of materials used as a biomaterial To assess the probable organism response on presence of selected biomaterial in the body To perform a critical assessment of degradation degree for various types of biomaterials in the living organism |
| Competences |
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| N/A |
| teaching methods |
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| Knowledge |
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| Lecture |
| Self-study of literature |
| Lecture with visual aids |
| Task-based study method |
| Multimedia supported teaching |
| Skills |
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| Practicum |
| Individual study |
| Multimedia supported teaching |
| Competences |
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| Multimedia supported teaching |
| Lecture with visual aids |
| Lecture |
| assessment methods |
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| Knowledge |
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| Combined exam |
| Oral exam |
| Written exam |
| Skills |
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| Individual presentation at a seminar |
| Skills demonstration during practicum |
| Competences |
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| Oral exam |
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Recommended literature
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Bhat, S.V. Biomaterials, Second Edition. ISBN 978-1842652077.
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Ľubomír Medvecký , kolektiv autorů. Biomateriály na báze fosforečnanov vápenatých ? vlastnosti a aplikácie. Slovensko, 2024.
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María Vallet-Regí. Bioceramics with Clinical Applications. United Kingdom. 2014.
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P. S. Liu, G. F. Chen. POROUS MATERIALS: Processing and Applications. USA. 2014.
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Park, Joon Bu; Lakes, Roderic S. Biomaterials : an introduction. 3rd ed. New York : Springer, 2010. ISBN 978-1-4419-2281-6.
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Vladimír Starý, František Denk. Biomateriály a biotolerance. ČVUT Praha. 2020.
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William R. Wagner, Shelly E. Sakiyama-Elbert, Guigen Zhang, Michael J. Yaszemski. Biomaterials science : an introduction to materials in medicine. London. 2020.
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